Lack of Association between GSTM1 and GSTT Genotypes and Pancreatic Cancer Risk in Japan
نویسندگان
چکیده
3Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center Hospital, Kanagawa, 2Department of Public Health, Aichi Medical University School of Medicine, 6Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, 8Department of Preventive Medicine, Kyushu University Faculty of Medical Science, Fukuoka, 9Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 10Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, 11Department of Food and Nutrition, Gifu City Women’s College, Gifu, 7Department of Public Health, Sapporo Medical University School of Medicine, 12Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, 1Hepatobiliary and Pancreatic Section, Gastroenterological Division, Cancer Institute Hospital, 4Department of Internal Medicine, Tokyo Metropolitan Matsuzawa Hospital, 5Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 13Central Animal Division, 14Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan *For correspondence: [email protected] Abstract
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Glutathione S-transferases (GSTs; EC: 2.5.1.18) are a ubiquitous family of eukaryotic and prokaryotic phase II metabolic isozymes. Genes encoding GSTM1 (OMIM: 138350), and GSTT1 (OMIM: 600436) are members of class mu and theta, respectively. The most common polymorphism in the GSTM1 is a deletion of the whole GSTM1 gene with a lack of enzyme activity. A homozygous deletion in the GSTT1 has also...
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